Will Lexicon Pharmaceuticals’s Top Institutional Shareholders DOUBLE DOWN on These Hot Catalysts?

So far this year, Lexicon Pharmaceutical’s (NASDAQ:LXRX) shares are up 67.44 percent. Today, Lexicon published the results of studies of its LX4211 oral drug for type 2 diabetes in Clinical Pharmacology & Therapeutics, which follows up on previous results released this week and were positive. On Monday, the company reported clinical trial results for its experimental diabetes drug LX4211. It said the drug had worked better at decreasing patients’ blood sugar levels than a placebo and that they had seen greater weight and blood pressure losses, reported Bloomberg. The clinical trial had lasted 12 weeks and included almost 300 patients. The company ill begin a late-stage clinical trial in 2013’s first half.

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With news of the positive clinical trials, will Lexicon Pharmaceuticals’ largest shareholders increase their holdings? 93 institutional firms indicated owning shares of Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) in Q1 2012. These firms reported owning a total of 435.986 million shares on 03/31/2012. The shares closed at $1.86 on 03/31/2012.

Here are the ten largest positions in Lexicon Pharmaceuticals, Inc. at the end of March 31st, 2012.

Ulys LLC held 280,154,744 shares on 03/31/2012 worth $521,087,828. This brought the portfolio total to 39.16%.

FMR LLC held 71,529,554 shares on 03/31/2012 worth $133,044,971. This brought the portfolio total to 0.02%.

Price T Rowe Associates Inc /MD/ held 14,340,516 shares on 03/31/2012 worth $26,673,360. This brought the portfolio total to 0.01%.

Vanguard Group Inc held 12,296,000 shares on 03/31/2012 worth $22,870,560. This brought the portfolio total to 0.0%.

Nea Management Company LLC held 11,676,000 shares on 03/31/2012 worth $21,717,360. This brought the portfolio total to 0.85%.

Blackrock Fund Advisors held 7,512,706 shares on 03/31/2012 worth $13,973,633. This brought the portfolio total to 0.01%.

Royce & Associates LLC held 7,399,860 shares on 03/31/2012 worth $13,763,740. This brought the portfolio total to 0.04%.

Blackrock Institutional Trust Company N.A. held 4,957,654 shares on 03/31/2012 worth $9,221,237. This brought the portfolio total to 0.0%.

Schroder Investment Management Group held 3,949,100 shares on 03/31/2012 worth $7,345,326. This brought the portfolio total to 0.02%.

Jpmorgan Chase & Co held 3,404,242 shares on 03/31/2012 worth $6,331,890. This brought the portfolio total to 0.0%.

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